Joint Homing Peptides Targeting Rheumatoid Arthritis
UMB CELA (Commercial Evaluation License Agreement)
Rheumatoid Arthritis (RA)
- 1.3M U.S. adults suffer from RA
- The most common autoimmune disease in U.S.
- U.S. market for RA drugs expected to reach $63 billion by 2027
- Development plan to utilizing liposomal Homing Peptide to deliver targeted psilocybin
- The ability of the peptides to target inflamed epithelium suggest they could be used to target drug delivery. This approach could enhance the therapeutic effect of current and future therapies and decrease potential systemic toxicity despite systemic administration of the drug. These peptides have potential for the development of fusion imaging molecules and/or nanoparticles to study arthritic pathogenesis. They could also be customizable and used to deliver nanoparticles for precise imaging. In addition, these novel joint-homing peptides can be used to treat autoimmune diseases, including but not limited to RA.
- Identify markers of arthritic inflammation in joints
- Isolate phage clones that preferentially target inflamed joints of arthritic Lewis rats
- Peptide significantly inhibited arthritic progression in this animal model
- Further studies are underway at UMB